Acerola Cherry |
J Nutr Sci Vitaminol ( Tokyo ). 2002 Feb;48(1):69-72.
Effect of acerola cherry extract on cell proliferation and activation of ras signal pathway at the promotion stage of lung tumorigenesis in mice.
Nagamine I, Akiyama T, Kainuma M, Kumagai H, Satoh H, Yamada K, Yano T, Sakurai H.
Department of Agriculture and Biological Chemistry, College of Bioresource Sciences, Nihon University , Fujisawa , Kanagawa , Japan .
The present study was undertaken to estimate the effect of acerola cherry extract (ACE) pretreatment on cell proliferation and the activation of Ras signal pathway at a promotion stage of lung tumorigenesis in mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Pretreatment with ACE (dose, 70mg/kg body weight and 700 mg/kg body weight) inhibited increases in the levels of proliferating nuclear cell antigen and ornithine decarboxylase at the promotion stage. This treatment of ACE also suppressed the activation of Ras signal pathway at the same stage. These results suggest that ACE regulates abnormal cell growth at the promotion stage of lung tumorigenesis in mice treated with NNK as a result of suppression of the initiation stage.
Source: PubMed
http://www.ncbi.nlm.nih.gov/pubmed/12026193
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Antihyperglycemic Effect of Polyphenols from Acerola ( Malpighia emarginata DC.) Fruit |
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Takayuki HANAMURA1), Chisato MAYAMA1), Hitoshi AOKI1), Yasushi HIRAYAMA2) and Makoto SHIMIZU3) |
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1) Research and Development Division, Nichirei Foods Inc. |
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(Received November 1, 2005) |
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A crude acerola polyphenol fraction (C-AP) was prepared by subjecting an acerola extract to a C18 cartridge column, and eluting the adsorbed fraction with ethanol containing 10% of acetic acid. C-AP appeared in a previous study to have an inhibitory effect on α-glucosidase and particularly on maltase activities. To elucidate the antihyperglycemic effect of C-AP further, we examined the regulation by C-AP of glucose uptake in Caco-2 cell; this resulted in the inhibition of glucose uptake. We next conducted single administration tests of glucose and maltose to ICR mice to investigate whether C-AP really controlled the intestinal glucose absorption in an animal body. The results showed that C-AP significantly suppressed the plasma glucose level after administering both glucose and maltose, suggesting that C-AP had a preventive effect on hyperglycemia in the postprandial state. The mechanism for this effect is considered to have been both suppression of the intestinal glucose transport and the inhibition of α-glucosidase. |
Source: PubMed
http://www.jstage.jst.go.jp/article/bbb/70/8/70_1813/_article